Press Release: Grant Announcement FAPERJ-IDOR

“The D’Or Institute for Research and Education (IDOR) and FAPERJ will soon release a funding opportunity announcement for a clinical and translational research grant, whose main goals are (1) to promote scientific advancement, the establishment and consolidation of research networks involving teams from IDOR and from other Institutions from Rio de Janeiro, Brazil and abroad; (2) to promote the development of innovation initiativesin technologies, services and products in the biomedical sciences with high potential for application or for changing conceptual paradigms in health sciences. R$ 10,000,000.00 will be granted over a 3 year period (half provided by IDOR through Rede D’Or São Luiz Hospitals Group, its main sponsor, and half by FAPERJ), which may be used to fund fellowships, field work, equipment, third-party services and scientific visits of researchers from other Brazil states or from abroad, for a flexible amount of time. The 1st round will consist on the analysis of Intention Letters (1-2 pages) which must describe (1) motivation (2) originality and importance and (3) the translational potential and the applicability of the project. The 2nd round will consist on the development of synergistic theme projects involving the most promising propositions from the 1st round, through an interaction between the Grant Managing Committee and the proponents, followed by a new selective round after the re-submission of the integrated propositions. High-risk and high-originality propositions are encouraged, as well as propositions that foster the development of national and international institutional collaborations, the repatriation of young Brazilian scientists and the integration of researchers from abroad.”

Theme lines for the propositions are: (1) Neurosciences and neuropsychiatry (structural and functional neuroimaging, neurotechnology, molecular mechanisms and signaling pathways, computational modeling, neuroplasticity, brain-machine interfaces, stroke); (2) Inflammatory, autoimmune, neoplastic, degenerative and vascular diseases (intensive medicine, molecular and metabolic mechanisms in sepsis and infectious syndromes, metabolic, genetic and image markers in aging, dementia, cardiovascular, respiratory, gastrointestinal, kidney and liver diseases, severity and prognostic markers); (3) Cost-effectiveness and quality in medicine ( introduction of new diagnosis, treatment and monitoring technologies, new procedures and products, pharmacoeconomics, management and control in high complexity hospital environments, emergency medicine, quality and impact metrics).

The Institute

The D’Or Institute for Research and Education (IDOR) is a nonprofit organization whose aim is to promote scientific and technological progress in healthcare. IDOR has its own headquarters since 2010 but its origin dates back to the creation of the Rede D’Or hospitals group, its main sponsor. Since the establishment of its hospitals network, Rede D’Or São Luiz Group has promoted numerous education and clinical research initiatives, including education and specialization programs. Graduate level education programs (lato sensu), residency programs, and specialization courses were created, as well as fellowships for undergraduate students and for medical physicists, many in partnership with public universities. The scientific committee, the institutional review board (human research ethics committee, tied to the CONEP, an organ of the Brazilian Ministry of Health), and a science diffusion center were all established during the past decade.

Since 2010, when it was formaly established, IDOR operates in its own headquarters, located in Rio de Janeiro, and is responsible for designing, planning and overseeing most of the educational and research activities conducted intramurally in Rede D'Or São Luiz. IDOR also independently seeks new opportunities for scientific collaborations with other institutions and investigators, with the goal of bringing innovative ways to foster scientific research, education and awareness.

Research currently conducted at IDOR encompasses the following lines: neurosciences, intensive care medicine, internal medicine and imaging.

Residency programs and graduate education programs (lato sensu) are offered in coordination with the research activities.

IDOR has a comprehensive annual program of continuing education comprising seminars, lectures, learning round-ups, theoretical courses, hands-on courses and workshops.

IDOR also maintains partnerships with graduate education programs (stricto sensu) from selected public universities at the Rio de Janeiro state, as well as scientific cooperation agreements with several Brazilian and international research and education organizations. For an overview of publications from IDOR researchers, see: Publications

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Research

Neurosciences

I. Emphasis on the investigation of the neural and behavioral mechanisms related to social cognition and moral judgments, emotion and motivation, decision-making, anatomic and functional neuroplasticity, neurobiology of neurologic diseases and neuroinformatics

II. Description of cellular, molecular and metabolic aspects associated to psychiatric diseases through the use of induced pluripotent stem cells (iPS).

Publications

Research Lines

Anatomic and Functional Neuroplasticity: Evaluation of the neuroanatomical foundations of brain development, neural degeneration and neural plasticity in rodents and humans using quantitative Magnetic Resonance Imaging methods.

Cognitive Neuroscience and Neuroinformatics: Special focus on moral cognition and emotion, social behavior and decision making. Neuroinformatics research comprises the development and application of computational models to neuroimaging and the development of software/hardware integration tools (such as Brain-Computer Interfaces, BCIs).

Clinical Neurology: Methods for the diagnosis and prognosis of neurologic diseases, such as Parkinson’s disease, Alzheimer’s and stroke.

Neuropsychiatry: Focus on the investigation of clinical aspects, medical comorbidities, cognition, neurobiology and treatment of several neuropsychiatric disorders, including OCD, ADHD, major depression and antisocial personality disorder.

Biotechnological platform for the high throughput prospection of compound with therapeutic application in schizophrenia: Generation of human induced pluripotent stem cells from fibroblasts isolated from the skin of patients with mental disorders aiming a biotechnological application. Description of atomic, cellular, metabolic, and of gene expression in neural progenitors and neurons generated from iPS cells from patients with schizophrenia, compared to matched cells from healthy volunteers.

Principal Investigators

Fernanda Tovar Moll MD, PhD

Researcher

Gabriel R. de Freitas, MD, PhD

Researcher

Jorge Moll Neto, MD, PhD

Researcher

Leonardo Fontenelle MD, PhD

Researcher

Paulo Mattos MD, PhD

Researcher

Ricardo de Oliveira Souza, MD, PhD

Researcher

Stevens Rehen, PhD

Researcher




Intensive Care Medicine

Development of clinical studies associated to the management of critically ill patients

Publications

Research Lines

Sepsis and Systemic Inflammation: Investigation of the epidemiological aspects and identification of biomarkers for the diagnosis and prognosis of sepsis patients. Establishment of the key physiopathological mechanisms of the interaction between inflammation and metabolism as determinants of organic dysfunctions with a focus on: sepsis, dengue fever, pneumonia and influenza

Acute Pulmonary Lesion and Mechanical Ventilation: Identification of risk factors and physiopathological mechanisms involved in Acute Pulmonary Lesion (APL). Development of new mechanical ventilation technologies and practices for patients with APL and Acute Respiratory Distress Syndrome (ARDS). Development of imaging techniques for the evaluation of APL patients.

Prognosis of Critically Ill Patients: Evaluation of factors and prognostic indexes. Focus on: Management of cancer patients in ICU; Quality of life; Improving quality of assistance and management protocols.

Cognitive Dysfunction in the ICU: Epidemiology, mechanisms and long-term impacts.

Principal Investigators

Fernando Augusto Bozza MD, PhD

Researcher

Jorge Ibrain Figueira Salluh MD, PhD

Researcher

Marcio Soares MD, PhD

Researcher




Internal Medicine

Investigation of the clinical, diagnostic and therapeutic aspects of diseases.

Publications

Research Lines

Liver Diseases:

Non-Alcoholic Fatty Liver Disease (NAFLD): Studies of NAFLD in risk groups (diabetic and obese patients) and on the application of MRI for the diagnosis of occurrence and severity of NAFLD.

Non-Invasive Markers of Fibrosis: Research on predictive scores and non-invasive methods (laboratory and imaging) for the evaluation of hepatic fibrosis.

Hepatic cirrhosis and its complications: Evaluation of the efficacy of diagnostic methods (psychometric, laboratory and imaging) and prognostic factors in different complications of cirrhosis.

Gastrointestinal Diseases:

Digestive Endoscopy: Studies about diagnostic methods and prognostic factors on gastrointestinal diseases.

Cardiovascular diseases:

Diagnostic Imaging: Study of diagnostic imaging methods on the evaluation of cardiac diseases such as coronary artery disease, non-ischemic cardiomyopathy and cardiac arrhythmias.

Principal Investigator

Clerio Azevedo MD, PhD

Researcher

Renata Perez MD, PhD

Researcher




Imaging

Investigation of pulmonary inflammation through molecular imaging

Publications

Research Line

Pulmonary Inflammation: Investigation of pulmonary inflammation by means of clinical and experimental models, using Computerized Tomography (CT Scan), Positron Emission Tomography with CT Scan (PET-CT) and functional studies using Magnetic Resonance Imaging (MRI).

Principal Investigator

Rosana Souza Rodrigues MD, PhD

Researcher

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