OUR STORY

Research, Tech Innovation and Education together.

The D’Or Institute for Research and Education (IDOR) is a private and nonprofit organization whose aim is to promote scientific research and technological progress in healthcare and excellence in education.

The institute was founded in 2010 by the physicians Jorge Moll Neto and Fernanda Tovar-Moll. Its modern headquarters is located in Botafogo, Rio de Janeiro. IDOR has facilities and state-of-the-art equipment for scientific research and it is also partially supported by the Rede D’Or São Luiz hospitals group, its main sponsor. IDOR also coordinates activities of education and innovation from the Rede D’Or São Luiz, creating opportunities for the interaction between other academic and technological institutions.

IDOR believes in the importance of investing in education and the training of healthcare professionals. We offer specialization courses, professional training and academic internships, as well as medical residency programs approved by the Ministry of Education and Culture (MEC).

Our research effort stands out due to the quality and productivity of our science team, and to our modern infrastructure, which enables several research initiatives, especially in the fields of Neurosciences, Intensive Medicine, Internal Medicine, Pediatrics and Oncology.

Our mission

To be a research and education institution of excellence, offering unique products and services in healthcare and biotechnology.

Our goals

To be recognized nationally and internationally as an innovative private institution of research and education in healthcare.

INFRASTRUCTURE

IDOR has a modern headquarters with laboratory infrastructure, as well as access to a technological park, imaging equipment and infrastructure from  32 hospitals of D’Or São Luiz Network and 35 oncology clinics recently acquired by the group.

In 2014, we opened an advanced Molecular Biology and Cellular Reprogramming Laboratory, a $7-million investment. With over 250 m² of grounds and equipped through a partnership with BNDES and Finep, it includes cellular culture and molecular biology rooms, a robotic system for pharmaceutical screening, and an area for cellular therapy clinical essays.

Our high-technology equipment allows us to analyze the effect of drugs in lab-grown human tissue and to observe in detail, and in an automated way, molecular and cellular alterations. Our infrastructure, allied to our skilled team, lets us identify the biological and therapeutical potential of drugs, contributing to the pipeline of new medicine discovery.

Currently, IDOR’s laboratory is the only one in Latin America able to produce reprogrammed stem cells from urine, a non-invasive and practical method.

More recently, in 2016, alongside RDSL, IDOR modernised its Neuromodulation Laboratory. Equipped with electroencephalogram (EEG) systems, Transcranial Magnetic Stimulation (TMS), repetitive TMS (rTMS),

Transcranial Stimulation Direct Current (tDCS), neuronavigation, among other technologies for the development of multidisciplinary research, relies now on next-generation 3-tesla magnetic resonance imaging (MRI), which represents the state-of-the-art technology, considered the most modern equipment ever produced within this
category.

 Integrated to these tools is the Image Processing Laboratory, which has servers dedicated to process, analyze, store and backup images, graphic processors with GPU technology (Graphics Processing Unit), besides several high performance work stations with remote access. The lab allows the development of sophisticated statistical algorithms, pattern recognition and multivariate analyses, facilitating the integration with multiple systems, brain-machine interfaces and virtual reality equipment.

 Another special feature is a processing and neurofeedback tool developed by IDOR, the FRIEND - Functional Real-time Endogenous Neuromodulation and Decoding, which integrates data from functional magnetic resonance and virtual reality scenarios. The tool is being used globally in diverse high-impact research centers.

Perkin Elmer cell::explorer: Sistema robótico de pipetagem, processamento e varredura de fármacos, contendo:

       - Operetta High Content Imaging System: Sistema de imageamento de alto conteúdo por microscopia automatizado com sistema confocal spinning disk e live chamber com CO2. Apresenta os modos campo claro, fluorescência e confocalidade. Capaz de adquirir e processar, de forma automatizada, conteúdos elevados de imagens de microscopia. Equipado para análises em tempo real de células viáveis (live cell imaging) com controle de temperatura e gases. Análises de apoptose, ciclo celular, diferenciação, migração, proliferação e morfológicas, rearranjo de citoesqueleto, FISH, gotículas lipídicas, expressão de proteínas, ativação de receptores, varredura de fármacos e RNAi.

       - Columbus image analysis system: Servidor de análise de resultados de alto conteúdo com algoritmos para análise celular de alto desempenho;

       - Plate::handler SX20 workstation: Sistema automatizado incluindo bancada de alta performance, servidor com o sistema de controle  automação plate::works e sistema de fluxo laminar classe 100 com filtros HEPA;

       - Janus standard liquid handling platform with 8-position Varispan arm: Sistema de pipetagem automatizado com 8 canais capaz de pipetagem com seringa e ponteiras;

       - Plate::handler II 5-axis robotic arm: Braço robótico para transporte de microplacas entre os equipamentos do sistema robótico;

       - Tecan InfiniTe M200 Pro Nanoquant: Leitor de microplacas multimodal com duplo injetor capaz de detectar absorbância, luminescência (flash e glow) e fluorescência (top e bottom) com altíssima precisão e sensibilidade. Utilizado em análises bioquímicas, celulares e ensaios imunológicos.

       - Liconic STX44 IC SA robotic incubator: Incubadora automatizada com 30 posições e capacidade para cultivo em hipóxia;

       - Biotek ELX406 microplate washer with syringe and peristaltic dispensers: Lavadora e dispensadora de microplacas automatizada de alta capacidade com sistema de lavagem adaptado para o manuseio de microplacas com células e dispensadores de seringa e peristáltico (esterilizável, para pequenos volumes).

       - Plate tilter: Módulo de inclinação de microplacas:

       - Inheco peltier modules (3): Módulos de aquecimento e resfriamento automatizados com sistema peltier;

       - 4-position lidhandling module: Destampador de microplacas automatizado com acesso ao braço robótico;

       - Barcode reader: Leitor de código de barras com acesso ao braço robótico;

Evos xl live microscope: Microscópio digital de alta performance sem ocular para registro de imagens de células em placas, frascos e microplacas;

Evos fl live microscope: Microscópio digital com sistema de fluorescência de alta performance sem ocular para registro de imagens de células em placas, frascos e microplacas;

Evos xl Core (3): Microscópio digital de alta performance sem ocular para manipulação de células em cabinas de segurança biológica e registro de imagens de células em placas, frascos e microplacas;

- XVivo cGMP workstation: Sistema de sala limpa cGMP auto-contido com pressão negativa, sensores e controle de processo para certificação de produção cGMP para terapia celular.

- Thermo CryoExtra High Efficiency Cryogenic Storage System: Sistema cGMP de armanazenamento de células em nitrogênio líquido fase vapor de alta eficiência, com preenchimento automático e sistema de monitoramento e alarme;

- Thermo CryoMed cGMP Controlled Rate Freezer: Sistema de cGMP para congelamento de células a

- Ante-salas cGMP dedicadas para: paramentação, recepção/despacho de materiais, criogenia e preparo de materiais.

- Area de Biologia Molecular, contando com:

        - Ion Torrent PGM™ System for Next-Generation Sequencing: Sequenciamento de nova geração. O sistema Ion PGM permite o sequenciamento de painéis compreendendo até centenas de genes, análises de aneuploidia, expressão gênica, sequenciamento de genomas microbianos. Essas aplicações são comumente empregadas em especialidades como câncer, doenças genéticas e microbiologia (vírus e bactérias).

        - StepOnePlus™ Real-Time PCR System: Sistema de PCR em tempo real. Plataforma utilizada para análises de expressão gênica quantitativa, genotipagem, expressão de microRNAs, análise de translocações cromossômicas, detecção de genes, carga viral, etc.

       - PCR convencional: Plataformas versáteis para a realização de diversas metodologias baseadas em PCR;

- Area de Microbiologia;

- Área de Microscopia Avançada contando com:

        - Microscópio confocal a laser Leica de última geração.

- Infraestrutura de gases, gerador e energia redundante.

Auditorium

Designed to combine beauty and comfort, the auditorium provides a great environment for lectures, seminars and events. With 77 seats, it is equipped with projectors, TV's, video conference system and internet, perfectly suitable for the activities of the Institute.