OUR STORY

Research, Tech Innovation and Education together.

The D’Or Institute for Research and Education (IDOR) is a private and nonprofit organization whose aim is to promote scientific research and technological progress in healthcare and excellence in education.

The institute was founded in 2010 by the physicians Jorge Moll Neto and Fernanda Tovar-Moll. Its modern headquarters is located in Botafogo, Rio de Janeiro. IDOR has facilities and state-of-the-art equipment for scientific research and it is also partially supported by the Rede D’Or São Luiz hospitals group, its main sponsor. IDOR also coordinates activities of education and innovation from the Rede D’Or São Luiz, creating opportunities for the interaction between other academic and technological institutions.

IDOR believes in the importance of investing in education and the training of healthcare professionals. We offer specialization courses, professional training and academic internships, as well as medical residency programs approved by the Ministry of Education and Culture (MEC).

Our research effort stands out due to the quality and productivity of our science team, and to our modern infrastructure, which enables several research initiatives, especially in the fields of Neurosciences, Intensive Medicine, Internal Medicine, Pediatrics and Oncology.

Our mission

To be a research and education institution of excellence, offering unique products and services in healthcare and biotechnology.

Our goals

To be recognized nationally and internationally as an innovative private institution of research and education in healthcare.

INFRASTRUCTURE

IDOR has a modern headquarters with laboratory infrastructure, as well as access to a technological park, imaging equipment and infrastructure from  32 hospitals of D’Or São Luiz Network and 35 oncology clinics recently acquired by the group.

In 2014, we opened an advanced Molecular Biology and Cellular Reprogramming Laboratory, a $7-million investment. With over 250 m² of grounds and equipped through a partnership with BNDES and Finep, it includes cellular culture and molecular biology rooms, a robotic system for pharmaceutical screening, and an area for cellular therapy clinical essays.

Our high-technology equipment allows us to analyze the effect of drugs in lab-grown human tissue and to observe in detail, and in an automated way, molecular and cellular alterations. Our infrastructure, allied to our skilled team, lets us identify the biological and therapeutical potential of drugs, contributing to the pipeline of new medicine discovery.

Currently, IDOR’s laboratory is the only one in Latin America able to produce reprogrammed stem cells from urine, a non-invasive and practical method.

More recently, in 2016, alongside RDSL, IDOR modernised its Neuromodulation Laboratory. Equipped with electroencephalogram (EEG) systems, Transcranial Magnetic Stimulation (TMS), repetitive TMS (rTMS),

Transcranial Stimulation Direct Current (tDCS), neuronavigation, among other technologies for the development of multidisciplinary research, relies now on next-generation 3-tesla magnetic resonance imaging (MRI), which represents the state-of-the-art technology, considered the most modern equipment ever produced within this
category.

 Integrated to these tools is the Image Processing Laboratory, which has servers dedicated to process, analyze, store and backup images, graphic processors with GPU technology (Graphics Processing Unit), besides several high performance work stations with remote access. The lab allows the development of sophisticated statistical algorithms, pattern recognition and multivariate analyses, facilitating the integration with multiple systems, brain-machine interfaces and virtual reality equipment.

 Another special feature is a processing and neurofeedback tool developed by IDOR, the FRIEND - Functional Real-time Endogenous Neuromodulation and Decoding, which integrates data from functional magnetic resonance and virtual reality scenarios. The tool is being used globally in diverse high-impact research centers.

PerkinElmer cell::explorer: Robotized pipetting, processing and drug screening system

> High content imaging system with automated spinning disk confocal microscopy and live cell chamber with CO2 and temperature control. This system is equipped with bright field illumination, digital phase contrast (DPC) and wide field fluorescence and confocal modes. It was designed to acquire and process, in an automated way, large contents of microscopy images. Equipped for real-time analysis of viable cells (live cell imaging) with temperature and gas control. Automated analysis of apoptosis, cell cycle, differentiation, migration, proliferation and morphology, cytoskeletal rearrangement, FISH, lipid droplets, protein expression, receptor activation, drug scanning and RNAi. 

> Columbus Image Analysis System. Browser based high content imaging analysis software with powerful analysis algorithms. This system is part of the HCS platform and is fully compatible with Operetta High Content Imaging System. 

> Plate::handler SX20 workstation. Automated system including high performance deck, automation server (plate:works) and class 100 laminar flow system with HEPA filter.

> JANUS liquid handling platform with 8-position Varispan arm. Automated pipetting system with 8 independent syringe or disposable tip channels. 

> Plate::handler II 5-axis robotic arm.  Robotic arm for plate moving across systems in cell::explorer platform.

> Tecan InfiniTe M200 Pro Nanoquant. Multimodal plate reader with dual injector geared with high precision and sensibility absorbance, luminescence (flash and glow) and fluorescence (top and bottom) detector. Used in biochemical, cellular and immune assays. 

> Liconic STX44 IC SA Robotic Incubator. Automated incubator with 30 slots capacity and hypoxia settings. 

> Biotek ELX406 micro plate washer. Automated high throughput micro plate washer and dispenser with syringe and peristaltic dispensers. 

> Plate Tilter. Micro plate tilting module for automatic aspiration. 

> Inheco Peltier Modules. Total of three heating and cooling automated modules with peltier system. 

> 4-position lid handling module. Micro plate lid remover with robotic arm access. 

> Barcode reader. Barcode reader for micro plates with robotic arm access. 

Cell culture equipments

> Evos xl live microscope. High performance inverted digital microscope with 24-bit color camera and 1024x768 pixels resolution LCD display. Features bright field and phase contrast imaging methods. 

> Evos fl live microscope. High performance inverted digital fluorescence microscope with CCD camera and 1024x768 pixels resolution LCD display. Features fluorescence, bright field and phase contrast imaging methods. 

> Evos xl Core (3). High performance inverted digital microscope with 24-bit color camera and 2048x1536 pixels resolution LCD display. Features bright field and phase contrast imaging methods. Used for cell culture manipulation inside bio-safety hoods. 

> Redundant gas, generator and energy infrastructure.     

> XVivo cGMP workstation. Clean room cGMP self contained system with negative pressure, sensors and process controls for production certification and cGMP production for cell therapy. 

> Thermo CryoExtra High Efficiency Cryogenic Storage System. High performance cGMP cell storage system in vapor phase liquid nitrogen, with automatic refill, monitoring system and alarm. 

> Thermo CryoMed cGMP Controlled Rate Freezer. cGMP system for cell freezing.

> Dedicated cGMP anteroom. gearing, material drop in/out, cryogeny and reagents preparation.

Molecular biology area

> Ion Torrent PGM™ System for Next-Generation Sequencing. This system permits sequencing of panels wit hundreds of genes, aneuploidy analysis, gene expression and microbe genome sequencing. These capabilities are usually applied in cancer research, genetic diseases and microbiology (virus and bacteria).  

> StepOnePlus™ Real-Time PCR System. Real time PCR used for quantitative gene expression analysis, genotyping, microRNA expression, chromossomal translocations, gene detections, viral load, etc. 

> Convencional PCR. Versatile polymerase chain reaction platforms for DNA amplification methodologies. 

Microbiology area

Advanced microscopy area

> State of the art Leica laser scanning confocal microscope. 

Auditorium

Designed to combine beauty and comfort, the auditorium provides a great environment for lectures, seminars and events. With 77 seats, it is equipped with projectors, TV's, video conference system and internet, perfectly suitable for the activities of the Institute.